Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.
Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium / Walton, E; Hibar, D. P; Van Erp, T. G. M; Potkin, S. G; Roiz-santiañez, R; Crespo-facorro, B; Suarez-pinilla, P; Van Haren, N. E. M; De Zwarte, S. M. C; Kahn, R. S; Cahn, W; Doan, N. T; Jørgensen, K. N; Gurholt, T. P; Agartz, I; Andreassen, O. A; Westlye, L. T; Melle, I; Berg, A. O; Morch-johnsen, L; Færden, A; Flyckt, L; Fatouros-bergman, H; Jönsson, E. G; Hashimoto, R; Yamamori, H; Fukunaga, M; Jahanshad, N; De Rossi, P; Piras, F; Banaj, N; Spalletta, G; Gur, R. E; Gur, R. C; Wolf, D. H; Satterthwaite, T. D; Beard, L. M; Sommer, I. E; Koops, S; Gruber, O; Richter, A; Krämer, B; Kelly, S; Donohoe, G; Mcdonald, C; Cannon, D. M; Corvin, A; Gill, M; Di Giorgio, A; Bertolino, A; Lawrie, S; Nickson, T; Whalley, H. C; Neilson, E; Calhoun, V. D; Thompson, P. M; Turner, J. A; Ehrlich, S.. - In: PSYCHOLOGICAL MEDICINE. - ISSN 0033-2917. - ELETTRONICO. - 48:1(2018), pp. 82-94. [10.1017/S0033291717001283]
Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium
De Rossi, P;
2018
Abstract
Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.| File | Dimensione | Formato | |
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